A scientific breakthrough for our cells
~90% of our cellular energy is produced by mitochondria
Mitochondria are our cellular powerhouses. The trillions of cells that comprise our body tissues run on the energy created by them.
Mitochondria are the bedrock of good health
Healthy cells rely on healthy mitochondria. Their optimal function leads to incredible health benefits, and is particularly essential to heart, kidney, eye, brain and muscle function. Our clinical science to date has focused on muscle health as muscle cells have a very large number of mitochondria.
Digestive system
The digestive system is essential to human well-being. Mitochondrial health has been associated with improved gut barrier health, a reduced risk of fatty liver disease, improved kidney function and lower risk of glucose intolerance.
Brain
The human brain uses about 25% of the human body’s metabolic energy and is particularly sensitive to the aging process. A growing number of scientists are looking into the contributions of mitochondria in brain health with preliminary studies suggesting they could be key players in brain disorders.
Immune system
The immune system protects us from infections and from excessive inflammation. With age, its control loosens up. Evidence is rising on the importance of mitochondria to reduce inflammation with aging, also known as inflamm-aging.
Heart
A 2018 report reviewed recent evidence implicating mitochondrial dysfunction in the development of heart failure. “Oxidative metabolism in mitochondria is the main energy source of the heart, and the inability to generate and transfer energy has long been considered the primary mechanism linking mitochondrial dysfunction and contractile failure.”
Joints
Joints are key for our mobility. The cells required to keep our joints functional progressively decline in function, and so do their mitochondria. These powerhouses need to be renewed and nourished to keep our joints healthy. There is emerging science around the link between mitochondria and arthritis.
Skeletal muscle
During strenuous exercise, the rate of energy use in skeletal muscles can increase by more than 100-fold almost instantly. To meet this energy demand, muscle cells contain mitochondria. Our clinical studies have shown improved muscle strength and endurance as a result of improved mitochondrial function.
As we age, mitochondrial function declines
Our mitochondria are constantly renewed to produce energy and fulfill the vast energy demands of muscle and other tissues. As we get older, mitochondrial renewal declines and dysfunctional mitochondria accumulate in the cells, resulting in significant issues.
Insufficient energy supply
Production of harmful molecules
Reduced cellular health
This decline starts earlier than you might think
Age-associated mitochondrial decline leads to a progressive decline in our metabolism, our overall energy levels, our resiliency and our muscle function.
Healthy aging
Average aging
Muscle function
Age
Healthy cells rely on a powerful recycling process
A process called mitophagy cleans up defective mitochondria and allows the mitochondria to repair themselves and improve their performance. This recycling and cleansing mechanism is proven to provide valuable health benefits.
Better mitochondria quality
Improved cellular health
Improved muscle strength
Meet Urolithin A, a rare molecule that renews our cellular powerhouses
Our scientists unlocked the power of Urolithin A, a molecule that stimulates this crucial recycling and cleansing process - ultimately protecting cells from age-associated decline.
Mitopure is a highly pure form of Urolithin A
While Urolithin A can be produced when eating certain foods, not everyone has the right gut bacteria to produce it. And even for those who can, our proprietary ingredient Mitopure delivers much purer and stronger levels than diet alone.** Read scientific evidence.
Diet only
500mg Mitopure™
Urolithin A Glucoronide (ng/ml)
Clinically proven to improve muscle function*
We conducted a randomized placebo-controlled clinical trial with adults aged 66 and older. After 2 months, participants who received a daily 1000mg dose of Mitopure (Urolithin A) had a significant improvement in hand and leg muscle endurance, compared with participants in the placebo group.
Change in leg muscle endurance
20%
15%
10%
5%
0%
2%
17%
Placebo
All made possible by a team of leading scientists
We are supported by the knowledge and guidance of an accomplished group of scientific and clinical advisors with expertise spanning microbiome science, genomics, metabolomics, gastroenterology, immunology, nutrition, and human clinical research.
Dr. Johan Auwerx MD, PhD
Scientific Advisor
Professor. Johan Auwerx directs the Laboratory for Integrated and Systems Physiology at École Polytechnique Fédérale (EPFL) in Lausanne, Switzerland, where he studies the mechanisms that control how metabolisms are controlled and the factors that make them more or less effective. Focusing on longevity, his team is using multiple animal species to test a specific compound, Urolithin A, which could potentially restore much-needed muscle strength and energy to people as they age. Prof. Auwerx is a scientific advisor to Amazentis.
Dr. Patrick Aebischer, MD
Chairman, Scientific Advisory Board
Professor Patrick Aebischer, chairman and co-founder of Amazentis, is a medical doctor, neuroscientist and longtime researcher. He has held distinguished positions in his home country of Switzerland, as President of the École Polytechnique Fédérale de Lausanne (EPFL) and in the United States at Brown University in Providence.
Dr. Carmen Sandi, PhD
Scientific Advisor
Director, Brain and Mind Institute and Professor at the EPFL, Lausanne, Switzerland | Neurobehavioral science and stress related brain disorders
Dr. Navindra Seeram, PhD
Scientific Advisor
Navindra P. Seeram, Ph.D, Professor in the College of Pharmacy at the University of Rhode Island. He is an expert in plants and products derived from them that can be used for medicinal purposes in humans. Navindra Seeram is a scientific advisor to Amazentis.
Dr. Michel Aguet, MD
Scientific Advisor
Professor Emeritus, EPFL, Lausanne Switzerland, Former Director of the Swiss Institute for Experimental Cancer Research (ISREC) | Cancer biology, molecular biology, stem cells and drug target validation
Eric Verdin, MD
Scientific Advisor
President and chief executive officer of the Buck Institute for Research on Aging
Roger Fielding, PhD
Clinical Advisor
Director and Senior Scientist of Nutrition, Exercise Physiology and Sarcopenia Laboratory, Tufts University | Exercise physiology, nutrition, sarcopenia
Jeremy D. Walston, MD
Clinical Advisor
The Raymond and Anna Lublin Professor of Geriatric Medicine and Gerontology Principal Investigator, Johns Hopkins Older Americans Independence Center Co-Director, Biology of Healthy Aging Program Johns Hopkins University School of Medicine | Geriatric medicine, chronic inflammation and mitochondrial biology, frailty research
