Exciting results from our latest clinical study. Read our article to get all the details.

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A scientific breakthrough for our cells

~90% of our cellular energy is produced by mitochondria

~90% of our cellular energy is produced by mitochondria

Mitochondria are our cellular powerhouses. The trillions of cells that comprise our body tissues run on the energy created by them.

~90% of our cellular energy is produced by mitochondria

Mitochondria are the bedrock of good health

Healthy cells rely on healthy mitochondria. Their optimal function leads to incredible health benefits, and is particularly essential to heart, kidney, eye, brain and muscle function. Our clinical science to date has focused on muscle health as muscle cells have a very large number of mitochondria.

Digestive system

The digestive system is essential to human well-being. Mitochondrial health has been associated with improved gut barrier health, a reduced risk of fatty liver disease, improved kidney function and lower risk of glucose intolerance.

Brain

The human brain uses about 25% of the human body’s metabolic energy and is particularly sensitive to the aging process. A growing number of scientists are looking into the contributions of mitochondria in brain health with preliminary studies suggesting they could be key players in brain disorders.

Immune system

The immune system protects us from infections and from excessive inflammation. With age, its control loosens up. Evidence is rising on the importance of mitochondria to reduce inflammation with aging, also known as inflamm-aging.

Heart

A 2018 report reviewed recent evidence implicating mitochondrial dysfunction in the development of heart failure. “Oxidative metabolism in mitochondria is the main energy source of the heart, and the inability to generate and transfer energy has long been considered the primary mechanism linking mitochondrial dysfunction and contractile failure.”

Joints

Joints are key for our mobility. The cells required to keep our joints functional progressively decline in function, and so do their mitochondria. These powerhouses need to be renewed and nourished to keep our joints healthy. There is emerging science around the link between mitochondria and arthritis.

Skeletal muscle

During strenuous exercise, the rate of energy use in skeletal muscles can increase by more than 100-fold almost instantly. To meet this energy demand, muscle cells contain mitochondria. Our clinical studies have shown improved muscle strength and endurance as a result of improved mitochondrial function.

Our mitochondria are constantly renewed to produce energy to fulfill the vast energy demands of muscle and other tissues. As we get older, mitochondrial renewal declines and dysfunctional mitochondria accumulate in the cells, resulting in significant issues.
Aging mitochondria cells

As we age, mitochondrial function declines

Aging mitochondria cells

Our mitochondria are constantly renewed to produce energy and fulfill the vast energy demands of muscle and other tissues. As we get older, mitochondrial renewal declines and dysfunctional mitochondria accumulate in the cells, resulting in significant issues.


Insufficient energy supply


Production of harmful molecules


Reduced cellular health

This decline starts earlier than you might think

Age-associated mitochondrial decline leads to a progressive decline in our metabolism, our overall energy levels, our resiliency and our muscle function.

Healthy aging

Average aging

Muscle function

Age

Healthy cells rely on a powerful recycling process

Healthy mitochondria cells

A process called mitophagy cleans up defective mitochondria and allows the mitochondria to repair themselves and improve their performance. This recycling and cleansing mechanism is proven to provide valuable health benefits.


Better mitochondria quality


Improved cellular health


Improved muscle strength

Meet Urolithin A, a rare molecule that renews our cellular powerhouses

Meet Urolithin A, a rare molecule that renews our cellular powerhouses

Our scientists unlocked the power of Urolithin A, a molecule that stimulates this crucial recycling and cleansing process - ultimately protecting cells from age-associated decline.

Meet Urolithin A, a rare molecule that renews our cellular powerhouses

Mitopure is a highly pure form of Urolithin A

While Urolithin A can be produced when eating certain foods, not everyone has the right gut bacteria to produce it. And even for those who can, our proprietary ingredient Mitopure delivers much purer and stronger levels than diet alone.** Read scientific evidence.

Diet only

500mg Mitopure™

Urolithin A Glucoronide (ng/ml)

Clinically proven to improve muscle function*

We conducted a randomized placebo-controlled clinical trial with adults aged 66 and older. After 2 months, participants who received a daily 1000mg dose of Mitopure (Urolithin A) had a significant improvement in hand and leg muscle endurance, compared with participants in the placebo group.

Change in leg muscle endurance


20%

15%

10%

5%

0%

2%

17%

Placebo

Mitopure

All made possible by a team of leading scientists

We are supported by the knowledge and guidance of an accomplished group of scientific and clinical advisors with expertise spanning microbiome science, genomics, metabolomics, gastroenterology, immunology, nutrition, and human clinical research.

  • Dr. Johan Auwerx MD, PhD

    Scientific Advisor

    Professor. Johan Auwerx directs the Laboratory for Integrated and Systems Physiology at École Polytechnique Fédérale (EPFL) in Lausanne, Switzerland, where he studies the mechanisms that control how metabolisms are controlled and the factors that make them more or less effective. Focusing on longevity, his team is using multiple animal species to test a specific compound, Urolithin A, which could potentially restore much-needed muscle strength and energy to people as they age. Prof. Auwerx is a scientific advisor to Amazentis.

  • Dr. Patrick Aebischer, MD

    Chairman, Scientific Advisory Board

    Professor Patrick Aebischer, chairman and co-founder of Amazentis, is a medical doctor, neuroscientist and longtime researcher. He has held distinguished positions in his home country of Switzerland, as President of the École Polytechnique Fédérale de Lausanne (EPFL) and in the United States at Brown University in Providence.

  • Dr. Carmen Sandi, PhD

    Scientific Advisor

    Director, Brain and Mind Institute and Professor at the EPFL, Lausanne, Switzerland | Neurobehavioral science and stress related brain disorders

  • Dr. Navindra Seeram, PhD

    Scientific Advisor

    Navindra P. Seeram, Ph.D, Professor in the College of Pharmacy at the University of Rhode Island. He is an expert in plants and products derived from them that can be used for medicinal purposes in humans. Navindra Seeram is a scientific advisor to Amazentis.

  • Dr. Michel Aguet, MD

    Scientific Advisor

    Professor Emeritus, EPFL, Lausanne Switzerland, Former Director of the Swiss Institute for Experimental Cancer Research (ISREC) | Cancer biology, molecular biology, stem cells and drug target validation

  • Eric Verdin, MD

    Scientific Advisor

    President and chief executive officer of the Buck Institute for Research on Aging

  • Roger Fielding, PhD

    Clinical Advisor

    Director and Senior Scientist of Nutrition, Exercise Physiology and Sarcopenia Laboratory, Tufts University | Exercise physiology, nutrition, sarcopenia

  • Jeremy D. Walston, MD

    Clinical Advisor

    The Raymond and Anna Lublin Professor of Geriatric Medicine and Gerontology Principal Investigator, Johns Hopkins Older Americans Independence Center Co-Director, Biology of Healthy Aging Program Johns Hopkins University School of Medicine | Geriatric medicine, chronic inflammation and mitochondrial biology, frailty research

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. * 500mg Mitopure™ have been shown to (1) induce gene expression related to mitochondria function and metabolism and (2) increase the strength of the hamstring leg muscle in measures of knee extension and flexion in overweight 40-65 year olds. Data from two randomized double-blind placebo-controlled human clinical trials. ** 500mg Mitopure™ have been shown to deliver at least 6 times higher Urolithin A plasma levels over 24 hours (area under the curve) than 8 ounces (240ml) of pomegranate juice in a randomized human clinical trial.